Melanoma Research Foundation | KyleS | Activity https://forum.melanoma.org/user/kyles/activity/ Activity feed for KyleS. Fri, 17 Apr 2026 11:45:43 -0400 https://buddypress.org/?v= en-US 30 hourly 2 10c7f5c7476675b2eae5beef4804df6f KyleS replied to the topic Quality of life on Braftovi / Mektovi and I in the forum General Melanoma Community https://forum.melanoma.org/forums/topic/quality-of-life-on-braftovi-mektovi-and-i/#post-274431 Tue, 30 Mar 2021 18:13:19 -0400 It wasn’t quite heart failure level but my LVEF at baseline was I believe somewhere in the 60% range.  I had a follow-up echo 3 months later after starting the drugs and it had dropped to 50%.  I ended up reducing my Mektovi dosage and the follow-up echos after that showed my EF back in the 60% range.  It is a rare side effect but I felt fine wi…Read more

]]> 2425fb126679749d30c8a980f3416d48 KyleS replied to the topic Quality of life on Braftovi / Mektovi and I in the forum General Melanoma Community https://forum.melanoma.org/forums/topic/quality-of-life-on-braftovi-mektovi-and-i/#post-274428 Tue, 30 Mar 2021 15:40:17 -0400 I have been on Braftovi / Mektovi for a while now and the only issue that I had was a borderline low LVEF that was resolved with a dose reduction. It’s weird how some people get a full list of side effects while others get virtually nothing. I think one positive thing to look at is most of these side effects can be well managed with dose…Read more

]]> 4a16b7660f441caed261feb93d7bdc52 KyleS replied to the topic Mixed Results — looking for my next treatment option in the forum General Melanoma Community https://forum.melanoma.org/forums/topic/mixed-results-looking-for-my-next-treatment-option/#post-274417 Mon, 29 Mar 2021 03:14:36 -0400 Hi Amanda,

I have not done TIL, but I have had a positive result on multiple therapies. This list starts wayyyyyy back in 2006 – present.

Interferon
Chemobiotherapy SWOG 0008 trial
IMRT (Radiation one month)
High Dose Il2
Dabrafenib
Ipi/nivo + 13 nivo cycles + SBRT until I had to stop due to elevated ALT / AST.

Plus some surgeries in…Read more

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