The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Re: Tregs

Forums General Melanoma Community Tregs Re: Tregs

    jim Breitfeller
    Participant

      The science is coming in loud and clear. Remember I said blame it on the Tregs!!!!! Well Here is some conformation of that.

      Tamed T-Cells leave patients cancer-free
      Monday, 26 July 2010by Becky Crew

      The antigen-specific reaction of T-cells working with dendritic cells, which regulate the immune system.

      SYDNEY: The manipulation of specific immune cells in bone marrow transplants has left a number of patients cancer-free, giving new hope to leukemia and lymphoma sufferers, according to a recent study.

      A team lead by Sébastien Maury from the Service d’Hématologie Clinique, France, has shown for the first time that by depleting the regulatory T-cell (or Treg) population in donor tissue, patients suffering from very resistant forms of cancer can achieve complete remission.

      By identifying the Tregs’ influence on how a new immune system reacts to foreign elements, it’s hoped that this study will result in more successful cancer treatments using transplantation.

      Source: http://www.cosmosmagazine.com/news/3586/tamed-t-cells-leave-patients-cancer-free

      This study is proof of a concept which demonstrates that regulatory T-cell manipulation can have therapeutic effects in humans,” says Maury. “It opens the way to its application in various fields in medicine where the immune system needs to be ‘tolerised’ (by adding more regulatory T-cells) in autoimmune diseases or ‘un-tolerised’ (by their elimination) in cancer.”

      This Treg manipulation can be accomplished by Ipilimumab. Blocking the CTLA-4 receptor on the Tregs surpressing their tolarance.

    About the MRF Patient Forum

    The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

    The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

    Popular Topics