Re: Tregs

The science is coming in loud and clear. Remember I said blame it on the Tregs!!!!! Well Here is some conformation of that.

Tamed T-Cells leave patients cancer-free
Monday, 26 July 2010by Becky Crew

The antigen-specific reaction of T-cells working with dendritic cells, which regulate the immune system.

SYDNEY: The manipulation of specific immune cells in bone marrow transplants has left a number of patients cancer-free, giving new hope to leukemia and lymphoma sufferers, according to a recent study.

A team lead by Sébastien Maury from the Service d’Hématologie Clinique, France, has shown for the first time that by depleting the regulatory T-cell (or Treg) population in donor tissue, patients suffering from very resistant forms of cancer can achieve complete remission.

By identifying the Tregs’ influence on how a new immune system reacts to foreign elements, it’s hoped that this study will result in more successful cancer treatments using transplantation.

Source: http://www.cosmosmagazine.com/news/3586/tamed-t-cells-leave-patients-cancer-free

This study is proof of a concept which demonstrates that regulatory T-cell manipulation can have therapeutic effects in humans,” says Maury. “It opens the way to its application in various fields in medicine where the immune system needs to be ‘tolerised’ (by adding more regulatory T-cells) in autoimmune diseases or ‘un-tolerised’ (by their elimination) in cancer.”

This Treg manipulation can be accomplished by Ipilimumab. Blocking the CTLA-4 receptor on the Tregs surpressing their tolarance.