Re: Recurrences with brain mets from BRAF/MEK Drugs?

It is highly possible that a factor is that stage 4 patients taking the inhibitors are living longer, thus giving mel. more time  to get to the brain.  I went from deaths door to clear of disease for 7/8 months.  Then I developed mets to the brain lining.  If I'd croaked 7 months earlier it could have been from other complications, or simply gotten into the brain then as the disease progressed to end stage.If the inhibitors aren't crossing the barrier at all or as well as other areas then maybe the mel. is finding a foothold in the cns.  No way to know at this point.  For what it's worth my inhibitor response is hanging in there on the rest of my body (3 months), and I know my dr. has another patient who is still clear aside from the brain and he's been off the BRAF inhibitor for 6/8 mo. or so.

Amy