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Re: Please Reply to This.

Forums General Melanoma Community Please Reply to This. Re: Please Reply to This.

    jim Breitfeller
    Participant

      Kevin,

      Melanoma is not a death sentence. Your oncologist is using Chemotherapy to shed tumor-specific  antigens for presentation on the Dendritic Cells (DCs). Scientists have recently identified a population of DCs (merocytic DCs [mcDCs]) that potently primes both CD8+ and CD4+ T cells to cell-associated Ags upon uptake of apoptotic cells.(dying cells). If activation of these T cells don't occur, it may be due to the surpressive function of the Tregs and the tumor microenviroment.  Ipilimumab (Anti-CTLA-4) surpresses the Tregs fuction by blocking the B7 receptors. It is the "spark" needed to jumpstart you immune system to reconognize  the Melanoma.

      Yes, there is hope. We are near a major breakthrough, but we first have to verify the protocol.

      if you want to read about a success story of a stage IV patient, please read "Melanoma and the Magic Bullet". The story starts on page 16. It is my story. It can be found at Meanoma Missionary site.

      http://melanomamissionary.blogspot.com/

      http://www.box.net/shared/kjgr6dkztj

       "Melanoma and the Magic Bullet"

      "Today might be the worst day of your life…but tomorrow could be the best. You just have to get there."

      ~Unknown~

      Take care

      Jimmy B

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