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Re: Dinaciclib Clinical Trial
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Re: Dinaciclib Clinical Trial

› Forums › General Melanoma Community › Dinaciclib Clinical Trial › Re: Dinaciclib Clinical Trial

    • August 10, 2010 at 11:01 pm
    ValinMtl
    Participant

      Thanks for the advice James.  I will most definitely make sure that it doesn't prohibit me from 'ipi' afterwards.  Apparently, Stephen Hodi from Dana Farber was involved in http://clinicaltrials.gov/ct2/show/NCT01026324.

      The one I applied for is this: http://clinicaltrials.gov/ct2/show/NCT00937937

      I would definitely have waited for 'ipi' but arrival is getting later and later so given the option of having to use temodar (no results last time) and doing this I will opt to do this if I am allowed. My progression is really getting out of hand.

      I wish somebody had more info about it though…I do know that dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9; inhibition of CDK1 and CDK2 may result in cell cycle repression and tumor cell apoptosis…but I don't know of anybody having done it.  Val

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